Assistant Professor & PULSE Lab Director - Johns Hopkins University Department of Electrical and Computer Engineering Department of Biomedical Engineering Listening to the Sound of Light to Guide Surgeries Abstract Photoacoustic imaging offers “x-ray vision” to see beyond tool tips and underneath tissue during surgical procedures, yet no ionizing x-rays are required. Instead, optical fibers […]
From Ocular Biometry to Cellular Resolution – and Multifunctional OCT – Coherence Ranging and Imaging in the Human Eye over 35 Years Abstract In the mid 1980s, first applications of low coherence interferometry (LCI) to tissue metrology and analysis were reported. Starting from one-dimensional ocular biometry, the technology has evolved into a high-speed, 3-dimensional imaging […]
Harnessing Photons for Label-free Chemical Imaging, High-Precision Neuromodulation, and Killing of Superbugs Abstract Photons are unique in that they can directly interact with molecules, the foundation of life. I will give an overview of our biophotonics research at three levels of interactions. At the weak interaction regime, I will present label-free chemical microscopy utilizing spectroscopic […]
In vivo multiphoton microscopy of microvasculature and inflammation: Lessons from the brain and a look at the heart Abstract In vivo multiphoton microscopy enables the visualization of dynamics at the cellular scale and is an ideal tool for studying the interactions of cells in vivo. Such imaging has revealed the importance of maintaining vascular health, […]
Cell Mechanics by Light Abstract Living cells are active matter characterized by mechanical properties as stiffness and deformability and morphological parameters as shape and volume. Genetic or pathogenic modifications of these properties can affect cell behavior. Since these transformations are potential indicators in various pathologies, cell mechanics characterization has progressively gained interest. However, due to […]
Fluorophores with a Genome: DNA-Stabilized Silver Clusters as a New Class of Tunable Fluorophores for Microscopy and Biosensing Abstract Because near-infrared (NIR) electromagnetic radiation penetrates much farther into biological tissues than visible light, NIR microscopy allows for noninvasive imaging deep into tissues and even whole organisms. In the second near-infrared window (NIR-II: 1,000-1,700 nm), biological […]
Illuminating Biomarkers of Stroke with Diffuse Optical Spectroscopies Abstract Our research group specializes in the development and application of diffuse optical spectroscopies to study the brain. These non-invasive, light-based tools enable real-time bedside monitoring of microvascular hemodynamics. In this seminar, I will focus on our recent work that uses these tools to identify biomarkers of […]