Hierarchical Strategies Towards Biointerfacing With Soft Optoelectronic Materials Abstract The applications of functional nanomaterials towards biological interfacing continue to emerge in various fields, such as in drug delivery and tissue engineering. While the rational control of surface chemistry and mechanical properties have been achieved for several of these biocompatible systems, these biomaterials are rarely synthesized […]
Optical Dissection of Brain Capillary Function Abstract My laboratory uses in vivo multiphoton imaging and rodent models to shed light (quite literally) on regulation of cerebral blood flow. In particular, we have focused recent attention on the vast capillary networks that distribute blood throughout the brain. We use light to both visualize capillary structure and […]
Harnessing Physiological Forces to Drive Stem Cell Fate & Function Abstract I will be elaborating about how physical cues are crucial to embryonic development, morphogenic events, and tissue organization, but methods to differentiate cells from human induced pluripotent stem cells (hiPSCs) mainly rely on chemical cues. As such, the role of substrate stiffness, fluid shear […]
Lasers in Nano-Surgery and Nano-Medicine: Plasmonic Nanobubbles Abstract To improve the safety and efficacy of standards of care in diagnostics and treatment of clinically-challenging diseases including cancer, we combine the laser and nanotechnology approaches into a precise on-demand mechanical impact an nano-scale, a laser pulse-generated vapor nanobubble around plasmonic nanoparticles in target cells. This nano-event, […]
Tunable photonic nanostructures for laser pulse control and dynamic imaging Abstract For decades, nanofabrication has been the driving force behind the transformations in electronics. Light-based devices currently experience a similar transition: nanostructure-based photonic elements bear promise to revolutionize several key technology areas, such as telecommunications, augmented reality, remote sensing, and imaging. In this talk, I […]
Opportunities to Improve Clinical Outcomes with Intravascular Ultrasound (IVUS) in Lower Extremity Revascularizations Abstract Peripheral vascular disorders are prevalent and mounting health conditions, particularly in light of the aging population. Both acute and chronic arterial and venous disease result in excess morbidity and mortality and dramatically reduce health-related quality of life. Yet, despite the expanded […]
Technology Transfer and Entrepreneurship at UCI Abstract This seminar will discuss “technology transfer”, the process by which UCI (1) protects intellectual property (inventions and software) developed by its faculty, staff, researchers and grad students; and (2) commercializes this IP through licensing to an existing company or startup. Also discussed will be the services and resources […]
FLIM and Mitometer enable metabolic profiling and tracking phenotypic changes in mitochondria in cancer cells Abstract The hallmark of metabolic alteration of increase glycolysis, i.e. Warburg effect, in cancer cells together with atypical extracellular matrix structure may be responsible for tumor cell aggressiveness and drug resistance. While it is it known that tumor cells stiffen […]
Cardio-oncology; Advanced optoacoustic imaging methods for biomedical research and clinical diagnostics Abstract Optoacoustic imaging has achieved remarkable progress over the last decade, benefiting from coordinated developments in optical and ultrasound technology, probe chemistry, and imaging theory. The technique is increasingly attracting attention of the biomedical research community due to its excellent spatial and temporal resolution, […]
Environmental and Fiber Sensing with Structured Light Abstract Structured light is being widely used to revolutionize the technologies used in optical trapping, microscopy, astronomical metrology, optical communication, quantum information systems, and many others. One defines an optical wavefront that has been spatially shaped in its phase, polarisation or intensity as structured light. Prof. Lavery will […]