BLI Profiles

Petra Wilder-Smith

Associate Professor, Beckman Laser Institute
Director of Dentistry, Beckman Laser Institute

Phone:  949.824.7632

Research Abstract

Dr Wilder-Smith is Associate Professor and Director of Dentistry at the University of California, Irvine’s Beckman Laser Institute. She is a Fellow of the University of California, Irvine’s Comprehensive Cancer Center, and visiting Professor at Aachen University and lecturer at Loma Linda University.

Professor Wilder-Smith's research interests include the use of non-invasive optical techniques such as fluorescence for oral diagnosis, especially the early detection and monitoring of oral pre-cancerous and cancerous changes. Her work in this field over the past 20 years has resulted in much collaboration and more than 70 publications. She serves on many advisory boards, including the Medical Advisory Board to Cancer Research and Prevention Foundation, the Board of the American Society for Laser Medicine and Surgery, as well as the editorial boards of the journals Lasers in Surgery & Medicine and Journal of Biomedical Optics. Wilder-Smith also served on the board of the Diagnostics Group, International Association for Dental Research and is currently President-Elect of this prestigious group.

Selected Publications

Hammer-Wilson MJ, Nguyen V, Jung WG, Ahn Y, Chen Z, Wilder-Smith P. Detection of Vesicant-induced Upper Airway Mucosa Damage in the Hamster Cheek Pouch Model Using Optical Coherence Tomography. J. Biomed. Opt. 15: 016017, 2010. PMCID 2839801

DeCoro M, Wilder-Smith P. Potential of Optical Coherence Tomography for Early Diagnosis of Oral Malignancies (Invited paper). Expert Review of Anticancer Therapy 10: 321-329, 2010.

Kim CS, Ahn Y-C, Wilder-Smith P, Oh S, Chen Z, Kwon YJ. Efficient and facile delivery of gold nanoparticles in vivo using dissolvable microneedles for contrast-enhanced optical coherence tomography. Biomedical Optics Express 1: 106-113, 2010. PMCID 3005167

Holtzman JS, Osann K, Pharar J, Lee K, Ahn Y-C, Tucker T, Sabet S, Chen Z, Gukasyan R, Wilder-Smith P. Ability of optical coherence tomography to detect caries beneath commonly used dental sealants. Lasers in Surgery and Medicine 42: 752-759, 2010. PMCID 3369270

Wilder-Smith P, Holtzman J, Epstein J, Le A. Optical diagnosis in the oral cavity: an overview. Oral Diseases 16: 717-728, 2010.

Zhang Q, Su W, Shi S, Wilder-Smith P, Xiang AP, Wong A, Nguyen AL, Kwon B, Le AD. Human gingiva-derived mesenchymal stromal cells induce alternative activation of monocytes/macrophages and enhance cutaneous wound healing. Stem Cells 28: 1856-1868, 2010. (Cited as Top Story in Mesenchymal Cell News, Aug. 24, 2010.) PMCID 3114043

Le AD, Messadi DV, Epstein J, Wilder-Smith P. Toward multimodality oral cancer diagnosis in the XXI century: blending cutting edge imaging and genomic/proteomic definition of suspicious lesions. Bioinformation 5: 304-306, 2011. PMCID 3043353

Ahn YC, Chung J, Wilder-Smith P, Chen Z. Multi-modality approach to optical early detection and mapping of oral neoplasia. J. Biomedical Optics 16: 076007-1-7, 2011. PMCID 3146547

Stoianovici C, Wilder-Smith P, Choi B. Assessment of pulpal vitality using laser speckle imaging. Lasers in Surgery and Medicine 43: 833-837, 2011. PMCID 3307522

Zhang Q, Nguyen AL, Shi S, Hill C, Wilder-Smith P, Krasieva TB, Le AD. Three-dimensional spheroid culture of human gingival-derived mesenchymal stem cells enhances mitigation of chemotherapy-induced oral mucositis. Stem Cells and Development 21: 937-947, 2012. PMCID 3315752

Duong S, Youssef J, Pimenta P, Aguigam H, Zhang J, Calantog A, Pilch S, Masters JG, Wilder-Smith P. An imaging-based approach to the evaluation of xerostomia. Lasers in Surgery and Medicine 44: 482-489, 2012.

Calantog A, Hallajian L, Nabelsi T, Mansour S, Le A, Epstein J, Wilder-Smith P. A prospective study to assess in vivo optical coherence tomography imaging for early detection of chemotherapy-induced oral mucositis. Lasers in Surgery and Medicine 45: 22-27, 2013.

Mittal R, Balu M, Wilder-Smith P, Potma EO. Achromatic miniature lens system for coherent Raman scattering microscopy. Biomedical Optics Express 4: 2196-2206, 2013.

Mittal R, Balu M, Krasieva T, Potma EO, Elkeeb L, Zachary CB, Wilder-Smith P. Evaluation of stimulated Raman scattering microscopy for identifying squamous cell carcinoma in human skin. Lasers in Surgery and Medicine 45: 496-502, 2013. Selected as “Editors Choice” paper.


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