BLI Profiles

Bruce J. Tromberg

Director, Beckman Laser Institute
Director, Laser Microbeam and Medical Program
Professor, Biomedical Engineering
Professor, Department of Surgery

Phone:  949.824.8705
Fax: 949.824.8413
University of California
Beckman Laser Institute
Irvine, CA 92612
Mail Code: 1475

Research Interests

Diffuse Optics, Non-linear Optical Microscopy, Photodynamic therapy, Metabolic Imaging

Research Abstract

Dr. Tromberg is the Director of the Beckman Laser Institute and Medical Clinic (BLI) at the University of California, Irvine (UCI) and principal investigator of the Laser Microbeam and Medical Program (LAMMP), an NIH P41 National Biomedical Technology Center in the BLI. He is a Professor with joint appointments in the departments of Biomedical Engineering and Surgery and has been a member of the UCI faculty since 1990. Dr. Tromberg co-leads the Onco-imaging and Biotechnology Program in UCI’s NCI Comprehensive Cancer Center and the Translational Technology Program in UCI’s NIH-designated Institute for Clinical and Translational Science. His research spans the interdisciplinary fields of Biophotonics and Biomedical Optics with particular emphasis on the development of new technologies for medical imaging and therapy. Major areas of activity include Diffuse Optical Spectroscopy and Imaging, Non-linear Optical Microscopy, and Photodynamic Therapy. His work includes more than 300 publications and 18 patents in Biophotonics technologies and their application to problems in cancer, vascular disease, neuroscience, and critical care. He serves on several national advisory committees, including the Experimental Imaging Sciences Committee for the American College of Radiology Imaging Networks (ACRIN) and is a council member for the NIH National Institute of Biomedical Imaging and Bioengineering (NIBIB). Dr. Tromberg is the former editor-in-chief of the Journal of Biomedical Optics and is an editorial board member for the journals Measurement Science and Technology and Cancer Research. He has received several awards for his work, including the R&D 100 Award and the OE Magazine Technology Innovator Award, and is a Fellow of the International Society for Optical Engineering (SPIE) and the American Institute for Medical and Biological Engineers (AIMBE).

Selected Publications

1. Zoumi A, Yeh A, Tromberg BJ, Imaging Cells and Extracellular Matrix In Vivo using Second-Harmonic Generation and Two-Photon Excited Fluorescence, Proc. Nat. Acad. Sci., 99, 11014 – 11019, (2002).

2. Cuccia D, Bevilacqua F, Durkin AJ, Tromberg BJ Modulated Imaging: Quantitation and Tomography of Turbid Media in the Spatial Frequency Domain, Opt. Let., 30, 1354-1356, (2005).

2. Roblyer D, Ueda S, Cerussi A, Tanamai W, Durkin A, Mehta R, Hsiang D, Butler JA, McLaren C, Chen WP, Tromberg B. Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment. Proc Natl Acad Sci U S A. 108:14626-31, (2011).

3. Ueda S, Roblyer D, Cerussi A, Durkin A, Leproux A, Santoro Y, Xu S, O'Sullivan TD, Hsiang D, Mehta R, Butler J, Tromberg BJ. Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy. Cancer Res. 72(17):4318-28 (2012).

4. O'Sullivan TD, Cerussi AE, Cuccia DJ, Tromberg BJ. Diffuse optical imaging using spatially and temporally modulated light. J Biomed Opt. 17(7):071311 (2012).

5. Balu M, Mazhar A, Hayakawa CK, Mittal R, Krasieva TB, König K, Venugopalan V, Tromberg BJ. In vivo multiphoton NADH fluorescence reveals depth-dependent keratinocyte metabolism in human skin. Biophys J. 104(1):258-67 (2013).


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