BLI Profiles
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Bruce J. Tromberg
Director, Beckman Laser Institute
Director, Laser Microbeam and Medical Program
Professor, Biomedical Engineering
Professor, Department of Surgery
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| University of California
Beckman Laser Institute
Irvine, CA 92612
Mail Code: 1475 |
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Research Interests
lasers, near infrared spectroscopy, non-invasive diagnostics, photomedicine, biomedical optics, photodynamic therapy
Research Abstract
Dr. Tromberg is the Director of the Beckman Laser Institute and Medical Clinic at the University of California, Irvine. He is Professor of Biomedical Engineering and Surgery, and former editor-in-chief of "The Journal of Biomedical Optics". Dr. Tromberg received his B.A. in Chemistry from Vanderbilt University and M.S. and Ph.D. degrees in Chemistry from the University of Tennessee where he was a U.S. Department of Energy Fellow at the Oak Ridge National Laboratory. Dr. Tromberg was a Hewitt Foundation Postdoctoral Fellow at the Beckman Laser Institute and has been a member of the Beckman faculty since 1990.
Dr. Tromberg's research interests are in the development and application of optical imaging and spectroscopy methods for non-invasive monitoring and imaging of physiological processes in cells and tissues. He and his group have developed broadband imaging technologies based on spatial and temporal modulation of light in order to measure the magnitude of light scattering and absorption in thick tissues at depths of several centimeters (http://lammp.bli.uci.edu/research/core.php?core=DOS/I). Dr. Tromberg is applying these techniques to in vivo functional imaging of cancer, vascular disease, and brain function in humans and pre-clinical animal models.
A second area of emphasis in the Tromberg lab is in the use of non-linear optical microscopy to generate high resolution functional maps of molecular processes in living cells and tissues. He is developing multi-dimensional technologies based on ultrafast lasers to visualize and quantify cell and tissue physiology with high spatial resolution (http://lammp.bli.uci.edu/research/core.php?core=MDM). These technologies are leading to a better understanding of the dynamics between cells, blood vessels, and extracellular matrix in cancer, vascular disease, and wound healing.
Dr. Tromberg has more than 300 publications and 10 patents in Biomedical Optics and Biophotonics. He has received several awards, including the UCI School of Medicine Athalie Clark Research Award, the Coherent Biophotonics Young Investigator Award, OE magazine's Technology Innovator award, the R&D 100 award, and is a Fellow of the International Society for Optical Engineering (SPIE), and the American Institute for Medical and Biological Engineers (AIMBE).
Selected publications
1. Zoumi A, Yeh A, Tromberg BJ, Imaging Cells and Extracellular Matrix In Vivo using Second-Harmonic Generation and Two-Photon Excited Fluorescence, Proc. Nat. Acad. Sci., 99, 11014 – 11019, (2002).
2. Cuccia D, Bevilacqua F, Durkin AJ, Tromberg BJ Modulated Imaging: Quantitation and Tomography of Turbid Media in the Spatial Frequency Domain, Opt. Let., 30, 1354-1356, (2005).
3. Cerussi A, Hsiang D, Shah N, Mehta R, Durkin A, Butler J, Tromberg BJ, Predicting Response to Breast Cancer Neoadjuvant Chemotherapy Using Diffuse Optical Spectroscopy Proc. Nat. Acad. Sci., 104(10), 4014-9, (2007)
4. Kukreti, S, Cerussi, A, Tanamai, W, Hsiang, D, Tromberg, B, Gratton, E, Characterization of Metabolic Differences between Benign and Malignant Tumors: High-Spectral-Resolution Diffuse Optical Spectroscopy, Radiology, 254(1), 277-284, (2010).
5. Chen, W-P, Tromberg, B. Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment, Proc. Nat. Acad. Sci. 108, 14626-14631 (2011)
My CV
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