UCI Beckman Laser Institute & Medical Clinic is committed to the dissemination of technologies through commercialization. In 1999, the Photonic Incubator at UCI Beckman Laser Institute & Medical Clinic was opened as one of the first incubators in the UC system. As part of the Institute’s expansion, the Photonic Incubator houses several start-up companies that collaborate with UCI Beckman Laser Institute & Medical Clinic faculty in the development of light-based medical devices.
CURRENT PHOTONIC INCUBATOR COMPANIES
UCI Beckman Laser Institute & Medical Clinic Spin-out and Incubating Companies
BitByte Dental Innovations, LLC (since 2017)
BitByte Dental Innovations, LLC develops clinical devices and instruments to improve dental practice and outcomes.
Cactus Medical, LLC (since 2019)
Cactus Medical, LLC is developing a new otoscope system to improve diagnosis of otitis media (ear infection) on the front line of care. Almost every child, approximately 90 percent, will have at least one ear infection before kindergarten. At roughly 30 million annual office visits, suspected ear infection is the second most common reason children are seen by a physician. Despite the frequency of cases, subjective reporting puts diagnostic certainty in primary care at approximately 60 percent. This makes otitis media the most common cause of unnecessary antibiotic use in children and the leading surgical indication in pediatrics. Cactus Medical’ s revolutionary Optical Tympanometry technology is 98 percent accurate and importantly, works through ear wax.
eLysis, Inc. (since 2020)
eLysis, Inc. was established to commercialize the electrochemical lysis of fat (ELF) technology. The ELF is an innovative, minimally invasive method of reducing fat for high precision facial and body contouring.
Incipian, LLC (since 2014)
Incipian, LLC is a medical research and development laboratory focused on creating energy-based medical therapeutics through collaborative studies with academic and industrial partners.
InfraDerm, LLC (since 2017)
InfraDerm, LLC is a start-up company co-founded by Drs. Mihaela Balu, associate researcher at the Institute; Bruce Tromberg, former Institute Director, and Christopher Zachary, Chair of the Department of Dermatology. A spin-out from the Nonlinear Optical Microscopy laboratory with Dr. Balu serving as principal investigator, InfraDerm is developing a fast, large area multiphoton exoscope device for clinical skin imaging. Potential applications include improving clinical diagnosis, particularly of skin cancers; guiding effective treatment and advancing clinical and cosmetic/pharmaceutical research by providing access to dynamic cellular and molecular processes during therapy.
Laser Associated Sciences, Inc. (since 2015)
Laser Associated Sciences, Inc. (LAS) develops light-based technology to measure peripheral blood flow and improve vascular care. In March 2020, LAS was acquired by Medtronic as the team continues to develop their flagship product, FlowMet. FlowMet is a noninvasive blood flow monitor designed to give real-time feedback regarding treatment efficacy during vascular surgery. In 2021, the team expects to launch the next generation of this technology.
Modulim (since 2006)
Modulim delivers transformative optical solutions that help people live healthier, longer lives. The Clarifi Imaging System, powered by Spatial Frequency Domain Imaging (SFDI) technology, helps clinicians identify compromised circulation at the point of care through non-contact rapid microvascular assessment of tissue. Clinicians and healthcare systems are empowered by SFDI images to make proactive, data-driven decisions in a multidisciplinary care setting, in order to reduce lower-limb complications caused by diabetes, kidney disease and peripheral arterial disease.
Founded by Institute alumnus and current chief technology officer, David Cuccia, Modulim is based in Irvine with a team dedicated to delivering powerful healthcare solutions that elevate and standardize health care delivery, while improving patient outcomes. Modulim received CE mark for the Clarifi Imaging System. The company placed multiple units at podiatry, dialysis and vascular clinics.
Multiphoton Laser Technology, Inc. (since 2011)
Multiphoton Laser Technology, Inc. (MPLT) was established by Dr. Karsten Koenig, former Institute postdoctoral fellow and CEO of JenLab GmbH located in Jena, Germany. MPTflex, a multiphoton tomography (MPT) device developed by MPLT, is based on ultrafast (femtosecond) laser technology. It is designed to perform non-invasive, high-resolution label-free imaging of human skin.
OCT Medical Imaging, Inc. (since 2008)
OCT Medical Imaging, Inc. is a medical device company that innovates and commercializes patented state-of-the-art, real-time, 3-D microendoscope technology for early detection, diagnosis and follow-up of vascular plaques and airway complications. OCT Medical Imaging recently moved to their new facilities in Irvine to continue commercialization of their microendoscope technologies.
Praxis Biosciences, Inc. (since 2012)
Praxis Biosciences, Inc. is focused on commercializing innovative and practical diagnostic solutions for biomedical research and healthcare industries. Technologies include a portable, non-invasive light-based imaging device for rapid, low-cost detection of sinus infections in children and an app-based device for personalized testing and augmentation of hearing.
Radoptics, LLC (since 2015)
Radoptics, LLC pursues the development and commercialization of optical probes derived from biological materials for medical imaging and phototherapeutic applications.
Collaborative Companies Incubating in UCI Beckman Laser Institute & Medical Clinic
Aracari Biosciences, Inc and NXT Biomedical, LLC vacated the Institute when Institute partner University Lab Partners (ULP) opened. The Institute played an important role in the conceptualization and establishment of ULP, while hosting the companies and providing needed wet laboratory space prior to the launch of ULP.
Lumitron Technologies, Inc. (since 2017)
Lumitron Technologies, Inc. (Lumitron), a start-up transplant to UCI and the Institute from the Lawrence Livermore National Laboratory, uses laser-Compton scattering to create tunable, monochromatic pencil-beam X-rays over a wide range of energies from 10keV to several MeV. Lumitron sources have the potential to be used in a wide range of medical, industrial and security applications.
Lumitron’s imaging system represents a landmark achievement in X-ray technology over the past 125 years. Potential medical applications include compression-free mammograms at one-100th the dose of existing technology, as well as selective cancer detection and treatment at the cellular level without patient movement. Additional medical diagnostics include low-dose imaging of pancreatic, colorectal, glioblastoma and lung cancers. The technology can empower – for the first time – the correlation between various metals (Fe, Cu, Cd, Pb et al) and neurological and other related diseases. In basic science, it will allow for molecular analysis studies using X-ray fluorescence and phase contrast imaging.
Photonics Management Corp (since 2019)
Photonics Management Corp owns Hamamatsu Photonics assets in North America. This includes the stock of Hamamatsu Corporation, the authorized distributor for Hamamatsu Photonics KK products, as well as Energetiq the manufacturer of EUV light sources and high brightness laser-driven light sources. In addition, Photonics Management is charged with looking for seed investments in start-ups that are using or developing photonics technology.
Their parent company is a world leader in photonics making a large variety of detectors, image sensors, lasers and lamps. Hamamatsu also produces end user products, such as scientific Complementary metal–oxide–semiconductor (sCMOS) cameras, digital slide scanners for pathology and back-end semiconductor failure analysis systems. Their products cover the electromagnetic spectrum from the X-ray to the terahertz.