Photonic Incubator

Beckman Laser Institute & Medical Clinic is committed to the dissemination of technologies through commercialization. The Photonic Incubator at Beckman Laser Institute & Medical Clinic was established in 1998 as one of the first incubators in the UC system. As part of the Institute’s expansion, the Photonic Incubator houses several start-up companies that collaborate with Beckman Laser Institute & Medical Clinic faculty in the development of light-based medical devices.

To learn more about the Photonic Incubator, please contact Deborah Birnie, Technology Transfer Manager, at 949.824.8517 or ddbirnie@uci.edu.

CURRENT PHOTONIC INCUBATOR COMPANIES

BitByte Dental Innovations, LLC (Since 2017)
BitByte Dental Innovations, LLC develops innovative clinical devices and instruments to improve dental practice and outcomes. With an expanding portfolio of products, their innovations include a novel approach for combating aerosol-transmitted disease (ATD). ATD is considered one of the most important barriers to clinician’s and patient’s health. Another device builds on decades of experience in oral cancer management. It harnesses smartphone-based techniques suitable for non-specialist use in high risk populations.

InfraDerm, LLC (Since 2017)
InfraDerm, LLC was established to develop cost-effective skin imaging devices based on multiphoton microscopy. InfraDerm technology provides label-free, sub-surface tomographic skin images with sub-cellular resolution. Applications include clinical research, diagnosis, and treatment monitoring for various skin conditions, including skin cancer.

Kino Biosciences, Inc. (Since 2017)
Developing successful cancer-fighting drugs averages 10-12 years and over $2.5 billion dollars. Yet, fewer than one in ten entering human clinical trials will succeed. Further, once new drugs become available, how do doctors choose which will work best for an individual patient? The mission of Kino Biosciences, Inc. is to lower the cost of drug development by compressing the timeline required to identify effective drug candidates and develop a precision drug sensitivity test that is focused on the individual patient. Today, most testing involves cancer cells grown in 2-D sheets, but human tumors are much more complex, multi-cellular, 3-D structures that alters their response to anti-cancer drugs. Kino Bioscience’s commercial human Vascularized Micro Tumor platform retains all of the properties of real human cancer.

Laser Associated Sciences, Inc. (Since 2015)
Laser Associated Sciences, Inc. develops light-based technology to measure peripheral blood flow and improve vascular care. LAS’s flagship product, FlowMet, is a noninvasive blood flow monitor designed to give real-time feedback during vascular surgery. LAS recently completed a 100-patient clinical study in which FlowMet measurements were successfully validated against standard techniques for assessing vascular health.

Lumitron Technologies, Inc. (Since  2017)
Lumitron Technologies, Inc., a start-up transplant to UCI and Beckman Laesr Institute & Medical Clinic from the Lawrence Livermore National Laboratory, uses laser-Compton scattering to create tunable, pencil-beam x-rays over a wide range of energies from 10keV to several MeV. Lumitron machines can be used in medical, industrial and security applications. Potential medical applications include compression-free mammograms, as well as selective cancer treatments.

Makani Science, Inc. (Since  2018)
The cost of poor medical compliance among children and adults with asthma and chronic obstructive lung disease (COPD) is a significant and growing burden to patient health and our healthcare system. Makani Science, Inc. is developing the world’s first Bluetooth-enabled, wearable respiratory sensor capable of monitoring the breathing rate, volumes, and velocities of its owner. Leveraging deep machine learning, this information can potentially be used to warn its owner of an impending asthma attack or COPD exacerbation. The form function is a tiny electronic chip affixed to a Band-Aid, which is placed on the person’s chest. Clinical testing has demonstrated proof-of-concept and statistical correlation with gold-standard spirometry.

Modulated Imaging, Inc. (Since  2006)
Modulated Imaging, Inc. develops light-based imaging devices that help healthcare professionals assess the health of tissue. Modulated Imaging received their first FDA clearance in December 2016 for the Ox-Imager CS®, a medical device that determines oxygenation levels in superficial tissue for patients with potential circulatory compromise. They are currently developing a next-generation device with a smaller footprint and faster image capture. They also offer a research system, Reflect RS®, a complete hardware and software solution that accurately measures subsurface tissue properties for a variety of basic science and pre-clinical research applications.

Multiphoton Laser Technologies, Inc. (Since  2011)
Multiphoton Laser Technologies, Inc. was established by Dr. Karsten Koenig, president of JenLab GmbH (Jena, Germany) and former BLIMC postdoctoral fellow. MPTflex is a multiphoton tomography (MPT) device that has been developed by Multiphoton Laser Technologies, which is based on ultrafast laser technology. It is designed to perform non-invasive, high-resolution label-free imaging of human skin.

OCT Medical Imaging, Inc. (Since  2008)
OCT Medical Imaging, Inc. is a medical device company that innovates and commercializes patented state-of-the-art, real-time, 3D microendoscope technology for early detection, diagnosis, and follow-up of vascular plaques and airway complications.

Praxis Biosciences, Inc. (Since  2012)
Praxis Biosciences, Inc. is a developmental stage company focused on commercializing innovative and practical solutions for biomedical research and healthcare industries. Technologies include a portable, non-invasive light-based imaging device for rapid, low-cost detection of sinus infections in children and an app-based device for personalized testing and augmentation of hearing. Praxis’ SinusCam, a diagnostic imaging device for the management of chronic sinusitis, is now undergoing clinical testing for its utility in the pediatric population.

Radoptics, LLC (Since  2015)
Radoptics, LLC pursues the development and commercialization of optical probes, derived from biological maerials, for medical imaging and phototherapeutic applications.

Reshape Life Sciences, LLC (Since  2015)
Reshape Life Sciences, LLC (dba ModaThera) is developing a laser system for cartilage reshaping to improve and correct functional and cosmetic malformations. The company’s technologies are based on minimally invasive approaches to alter the mechanical properties of cartilage tissues and thus providing significantly less trauma to the patient than that of a conventional surgical procedure. Reshape has been awarded an SBIR award for a Phase 1 study on “Development and Validation of EMR-Stent System for Treatments of Tracheal.”