Patents as of 1/26/2021

Title: Predicting weight loss and fat metabolism using optical signal changes in fat
Patent #: 10,827,974
Issued: November 10, 2020
Inventors: Robert Warren, Goutham Ganesan, Thomas O’Sullivan, Shaista Malik, Bruce J. Tromberg, Pietro Galassetti

Title: Non-invasive hemodynamic assessment via interrogation of biological tissue using a coherent light source
Patent #: 10,813,597
Issued: October 27, 2020
Inventors: Tyler Bywaters Rice, Michael Ghijsen, Bruce J. Tromberg, Bruce Yee Yang, Sean Michael White

Title: Continuous analyte sensor
Patent #: 10,750,985
Issued: August 25, 2020
Inventors: Elliot L Botvinick, John Weidling, Sean White

Title: Hand-held optical scanner for real-time imaging of body composition and metabolism
Patent #: 10,653,346
Issued: May 19, 2020
Inventors: Soroush Mohammad Mirzaei Zarandi, Bruce J. Tromberg, Thomas D. O’Sullivan, Siavash Sedighzadeh Yazdi, Albert Cerussi

Title: Imaging platform based on nonlinear optical microscopy for rapid scanning large areas of tissue
Patent #: 10,595,770
Issued: March 24, 2020
Inventors: Mihaela Balu, Eric O. Potma, Bruce J. Tromberg, Hideharu Mikami

Title: Integrated intraoperative diagnosis and thermal therapy system
Patent #: 10,568,687
Issued: February 25, 2020
Inventors: Zhongping Chen, Gangjun Liu, Jiawen Li, Lisa X. Xu, Aili Zhang

Title: Automatic three-dimensional segmentation method for OCT and Doppler OCT angiography
Patent #: 10,463,247
Issued: November 5, 2019
Inventors: Zhongping Chen, Lu Fan, Shenghai Huang

Title: Method to characterize cut gemstones using optical coherence tomography
Patent #: 10,458,921
Issued: October 29, 2019
Inventors: Matthew Brenner, Andrew Emon Heidari, Zhongping Chen, Sari Mahon,
Joseph Jing

Title: Method for extraction of spatial frequency information for quantitative tissue imaging
Patent #: 10,438,346
Issued: October 8, 2019
Inventors: Kyle Nadeau, Anthony J. Durkin, Bruce J. Tromberg

Title: Assessment of blood coagulation using an acoustic radiation force based optical coherence elastography (ARF-OCE)
Patent #: 10,365,254
Issued: July 30, 2019
Inventors: Zhongping Chen, Jiang Zhu, Xiangqun Xu

Title: Methods and systems for treating wounds
Patent #: 10,272,096
Issued: April 30, 2019
Inventors: Michael W. Berns, Ryan M. Spitler, Gerard Boss

Title: Integrated multimodality intravascular imaging system that combines optical coherence tomography, ultrasound imaging, and acoustic radiation force optical
coherence elastography
Patent #: 10,231,706
Issued: March 19, 2019
Inventors: Zhongping Chen, Wenjuan Qi, Rui Li

Title: Integrated ultrasound, OCT, PA and/or fluorescence imaging endoscope for diagnosing cancers in gastrointestinal, respiratory, and urogenital tracts
Patent #: 10,182,791
Issued: January 22, 2019
Inventors: Qifa Zhou, Xiang Li, Jacques Van Dam, K. Kirk Shung, Thomas Cummins, Zhongping Chen, Jiawen Li, Teng Ma

Title: Mechanical stress response analysis of cells and tissues
Patent #: 10,156,561
Issued: December 18, 2018
Inventors: Elliot L. Botvinick, Vasan Venugopalan, Jonathan Compton, Amy Hellman

Title: Measuring oxygen levels in an implant, and implants having incorporated oxygen sensing
Patent #: 10,149,640
Issued: December 11, 2018
Inventors: Elliot Botvinick, John Weidling

Title: Potential driven electrochemical modification of tissue
Patent #: 9,877,770
Issued: January 30, 2018
Inventors: Brian Jet-Fei Wong, Michael G. Hill, Dmitry E. Protsenko, Bryan Hunter

Title: Portable broadband diffuse optical spectroscopic imaging (DOSI) device for noninvasive tissue characterization
Patent #: 9,772,280
Issued: September 26, 2017
Inventors: Albert Cerussi, Bruce Tromberg, Keun-sik No, Brian Hill, Pai Chou

Title: Methods and compositions for treatment of cyanide and hydrogen sulfide toxicity
Patent #:9,534,007
Issued: January 3, 2017
Inventors: Gerry Boss, Adriano Chan, Matthew Brenner, Sari Brenner-Mahon, Vikhyat S. Bebarta, Jingjing Jiang, Karen Christman, Jean Wang Wassenaar

Title: Apparatus and method for capturing a vital vascular fingerprint
Patent #: 9,384,404
Issued: July 5, 2016
Inventors: Z. Chen, G.Liu

Title: Systems and methods for identifying and disrupting cellular organelles
Patent #: 9,321,990
Issued: April 26, 2016
Inventors: M. W. Berns, T. Pederson, E. Botvinick, L. Shi

Title: Method for optongenetic treatment of blindness including retinitis pigmentosa
Patent #: 9,089,698
Issued: July 28, 2015
Inventors: S. Mohanty, M. Ficinski, E. W. Wong, M. W. Berns

Title: Dynamic cooling of human skin using a nontoxic cryogen with no ozone depletion and minimal global warming potential
Patent #: 9,050,117
Issued: June 9, 2015
Inventors: J. Stuart Nelson, Lars O. Svaasand

Title: Concentration independent modulation of local micromechanics in a fibrin gel
Patent #: 8,844,369
Issued: September 30, 2014
Inventors: E. Botvinick, S. Shreim, M. Kotlarchyk

Title:Ultrasound guided optical coherence tomography photoacoustic probe for intravascular imaging
Patent #: 8,764,666
Issued: July 1, 2014
Inventors: Z. Chen, Q. Zhou, C. Hu, J. Yin, H. Yang, H. K. Chiang, K. Shung

Title: Rapid method to measure cyanide in biological samples
Patent #: 8,741,658
Issued: June 3, 2014
Inventors: Gerry Boss, Vijay Sharma, Matthew Brenner, Purnendu K. Dasgupta, William Curt Blackledge

Title: Apparatus and method for light emission detection for in-depth imaging of turbid media
Patent #: 8,692,998
Issued: April 8, 2014
Inventors: Enrico Gratton, Alexander Dvornikov, Viera Crosignani

Title: System and method for efficient coherence anti-Stokes Raman scattering endoscopic and intravascular imaging and multimodal imaging
Patent #: 8,582,096
Issued: November 12, 2013
Inventors: Z. Chen, G. Liu, M.Balu, B. J. Tromberg, E. Potma

Title: Apparatus and method for micromanipulation of microscale objects using laser light delivered through a single optical fiber and axicon lens
Patent #: 8,571,365
Issued: October 29, 2013
Inventors: S. Mohanty, J. Stephens, M. W. Berns

Title: Double bladed costal cartilage cutter
Patent #: 8,535,315
Issued: September 17, 2013
Inventors: A. Foulad, C. Manuel, B. J. F. Wong

Title: An apparatus and method for widefield functional imaging (WiFi) using integrated structured illumination and laser speckle imaging
Patent #: 8,509,879
Issued: August 13, 2013
Inventors: A. J. Durkin, D. Cuccia, B. J. Tromberg, A. Mazhar, B. Choi

Title: Systems, devices, and methods for optically clearing tissue
Patent #: 8,323,273
Issued: December 4, 2012
Inventors: Christopher G. Rylander, Thomas E Milner, Oliver Stumpp, J. Stuart Nelson, Ashley J. Welch, Kenneth R. Diller (it’s on the plaque)

Title: Method and apparatus for quantification of optical properties of superficial volumes using small source-to-detector separations
Patent #: 8,301,216
Issued: October 30, 2012
Inventors: Anthony J. Durkin, Sheng-hao Tseng

Title: An endoscopic long range, fourier domain optical coherence tomography (LR-FD-OCT)
Patent #: 8,285,368
Issued: October 9, 2012
Inventors: Z. Chen, J. Zhang, M. Brenner

Title: Three-dimensional breast anatomy imaging system
Patent #: 8,244,332
Issued: August 14, 2012
Inventors: B. J. Tromberg, A. Cerussi, F. Azar, A. Khamene, F. Sauer

Title: Method and apparatus for performing qualitative and quantitative analysis of produce (fruit, vegetables) using spatially structured illumination
Patent #: 8,014,569
Issued: September 6, 2011
Inventors: A. Durkin, D. Cuccia, B. J. Tromberg, F. Bevilacqua

Title: Method and apparatus for high resolution spatially modulated fluorescence imaging and tomography
Patent #: 7,729,750
Issued: June 1, 2010
Inventors: Bruce J. Tromberg, Anthony J. Durkin, David Cuccia, Frederic Bevilacqua

Title: Optical coherent tomographic (OCT) imaging apparatus and method using a fiber bundle
Patent #: 7,576,865
Issued: August 18, 2009
Inventors: Zhongping Chen, Tuqiang Xie, David Mukai, Matthew Brenner

Title: An immersion fluid applicator, for fluid immersion microscopy, housed in the microscope’s objective lens turret to allow for hands free delivery of immersion
fluid
Patent #: 7,532,393
Issued: August 26, 2009
Inventors: E. Botvinick, C. Rappaport, M.W. Berns

Title: Quantitative broadband absorption and scattering spectroscopy in turbid media by
combined frequency-domain and steady-state methodologies
Patent #: 7,428,434
Issued: September 23, 2008
Inventors: Bruce J. Tromberg, Andrew J. Berger, Albert E. Cerussi, Frederic Bevilacqua, Dorota Jakubowski

Title: Method and apparatus for the control and monitoring of shape change in tissue
Patent #: 7,416,550
Issued: August 26, 2008
Inventors: Dmitry E. Protsenko, Brian J. F. Wong, Guillermo Aguilar-Mendoza, Ki-Hong Kevin Ho, Sergio Diaz

Title: Method and apparatus for characterization of chromophore content and
distribution in skin using cross-polarized diffuse reflectance imaging
Patent #: 7,400,754
Issued: July 15, 2008
Inventors: Byungjo Jung, Bernard Choi, Anthony J. Durkin, J. Stuart Nelson

Title: High speed spectral domain functional optical coherence tomography and
optical doppler tomography for in vivo blood flow dynamics and tissue structure
Patent #: 7,359,062
Issued: April 15, 2008
Inventors: Zhongping Chen, Jun Zhang, J. Stuart Nelson

Title: In vivo port wine stain, burn and melanin depth determination using a
photoacoustic probe
Patent #: 7,322,972
Issued: January 29, 2008
Inventors: John A. Viator, Steven L. Jacques, J. Stuart Nelson, Guenther Paltauf

Title: Method and apparatus for quantification of optical properties of superficial layers
Patent #: 7,304,724
Issued: December 4, 2007
Inventors: Anthony J. Durkin, Sheng-Hao Tseng

Title: Methods of cytodiagnostic staging of neoplasia and squamous cell carcinoma
Patent #: 7,258,987
Issued: August 21, 2007
Inventors: Vickie J. LaMorte, Melinda Szendefi, Heinrich Walt

Title: Method and apparatus for performing second harmonic optical coherence
tomography
Patent #: 7,256,894
Issued: August 14, 2007
Inventors: Zhongping Chen, Yi Jang

Title: Method and apparatus for dynamically monitoring multiple in vivo tissue chromophores
Patent #: 7,248,909
Issued: July 24, 2007
Inventors: Jangwoen Lee, Bruce J. Tromberg, Albert E. Cerussi, Matthew Brenner

Title: Method and apparatus for detecting enzymatic activity using molecules that change electrophoretic mobility
Patent: 7,157,223
Issued: January 2, 2007
Inventors: Nancy J. Allbritton, Christopher E. Sims, Michael W. Berns, Gavin D. Meredith, Tatiana B. Krasieva, Bruce J. Tromberg, Chao L. Lee

Title: High resolution optical coherence tomography with an improved depth range using an
axicon lens
Patent #: 7,072,045
Issued: July 4, 2006
Inventors: Zhongping Chen, Zhihua Ding, J. Stuart Nelson

Title: Phase-resolved functional optical coherence tomography: simultaneous imaging
of the stokes vectors, structure, blood flow velocity, standard deviation and
birefringence in biological samples
Patent #: 7,016,048
Issued: March 21, 2006
Inventors: Zhongping Chen, J. Stuart Nelson

Title: Method and apparatus for performing quantitative analysis and imaging surfaces
and subsurfaces of turbid media using spatially structured illumination
Patent #: 6,958,815
Issued: October 25, 2005
Inventors: Frederic Bevilaqua, David Cuccia, Anthony J. Durkin, Bruce J. Tromberg

Title: Imaging transverse flow velocity using spectral bandwidth of the doppler frequency shift in phase-resolved optical doppler tomography
Patent #: 6,944,551
Issued: September 13, 2005
Inventors: Zhongping Chen, Hongwu Ren, J. Stuart Nelson

Title: System for real time, non0invasive metrology of microfluidic chips
Patent #: 6,868,347
Issued: March 15, 2005
Inventors: Guann-Pyng Li, Mark Bachman, Zhongping Chen

Title: Method and apparatus for measuring the heat transfer coefficient during cryogen
spray cooling of tissue
Patent #: 6,669,688
Issued: December 30, 2003
Inventors: Lars O. Svaasand, J. Stuart Nelson, Michael W. Berns, Sol Kimel

Title: Diffuse optics illuminator for reflectance microscopy and method of providing
diffuse light for reflectance microscopy
Patent #: 6,661,574
Issued: December 9, 2003
Inventors: Tatiana Krasieva, Alexander S. Dvornikov, Bruce J. Tromberg, Michael W. Berns

Title: Method and apparatus for cartilage reshaping by radiofrequency heating
Patent #: 6,589,235
Issued: July 8, 2003
Inventors: Brian J.F. Wong, Thomas E. Milner, Emil N. Sobol, Michael W. Keefe

Title: Phase-resolved optical coherence tomography and optical doppler tomography
for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity
Patent #: 6,549,801
Issued: April 15, 2003
Inventors: Zhongping Chen, Yonghua Zhao, J. Stuart Nelson, Johannes F. DeBoer

Title: Method and apparatus for detecting enzymatic activity using molecules that change
electrophoretic mobility
Patent #: 6,335,201
Issued: January 1, 2002
Inventors: Nancy L. Allbritton, Christopher E. Sims, Michael W. Berns, Gavin D. Meredith, Tatiana B. Krasieva, Bruce J. Tromberg

Title: Apparatus and method for dynamic cooling of biological tissues for thermal
mediated surgery using long laser pulses
Patent #: 6,248,103
Issued: June 19, 2001
Inventors: Sam Tannenbaum, Stuart Nelson, Thomas Milner, Bahman Anvari

Title: Birefringence imaging in biological tissue using polarization sensitive optical coherent tomography
Patent #: 6,208,415
Issued: March 27, 2001
Inventors: Johannes F. De Boer, Thomas E. Milner, J. Stuart Nelson

Title: Apparatus and method for dynamic cooling of biological tissues for thermal
mediated surgery
Patent #: 6,171,301
Issued: January 9, 2001
Inventors: J. Stuart Nelson, Thomas E. Milner, Lars O. Svaasand

Title: Fast controllable laser lysis of cells for analysis
Patent #: 6,156,576
Issued: December 5, 2000
Inventors: Nancy L. Allbritton, Christopher E. Sims, Michael W. Berns, Gavin D. Meredith, Tatiana B. Krasieva, Bruce J. Tromberg

Title: Apparatus and method to control atmospheric water vapor composition and
concentration during dynamic cooling of biological tissues in conjunction with
laser irradiations
Patent #: 5,997,530
Issued: December 7, 1999
Inventors: J. Stuart Nelson, Bahman Anvari, B. Samuel Tannenbaum, Thomas E. Milner

Title: Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media
Patent #: 5,991,697
Issued: November 23, 1999
Inventors: John Stuart Nelson, Thomas Edward Milner, Zhongping Chen

Title: Method and apparatus for causing rapid and deep spatially selective coagulation during thermally mediated therapeutic procedures
Patent #: 5,979,454
Issued: November 11, 1999
Inventors: Bahman Anvari, Samuel B. Tannenbaum, Thomas E. Milner, J. Stuart Nelson

Title: Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery
Patent #: 5,814,040
Issued: September 29, 1998
Inventors: J. Stuart Nelson, Thomas E. Milner, Lars O. Svaasand

Title: Fluorophore-polymer based illuminator for conventional light microscopy
Patent #: 5,734,498
Issued: March 31, 1998
Inventors: Tatiana Krasieva, Bruce Tromberg, Alexander Dvornikov, Michael W. Berns

Title: High resolution biosensor for in-situ microtherometry
Patent #: 5,631,141
Issued: May 20, 1997
Inventors: Greg J. Sonek, Yagang Liu, Bruce J. Tromberg, Michael W. Berns

Title: Intrauterine device for light diffusion and method of using the same
Patent #: 5,478,339
Issued: December 26, 1995
Inventors: Yona Tadir, Michael W. Berns, Lars O. Svaasand, Bruce J. Tromberg

Title: Vaginal speculum for photodynamic therapy and method of using the same
Patent #: 5,458,595
Issued: October 17, 1995
Inventors: Yona Tadir, Michael W. Berns, Brad J. Monk, Glen Profeta, Bruce J. Tromberg

Title: Apparatus and method for qualitative and quantitative measurements of optical properties of turbid media using frequency-domain photo migration
Patent #: 5,424,843
Issued: June 13, 1995
Inventors: Bruce J. Tromberg, Tsong T. Tsay, Michael W. Berns, Lars O. Svaasand, Richard C. Haskell