Year 4

Eight developmental projects, totaling $250,000 (total costs), were awarded in Year 4. Three new (E2, E3 and E8) projects were awarded, and five of the projects began their second year of funding.

 

Each application was reviewed based on innovation, relevance to Team 1 goals, and investigators. Funds were awarded to these projects because they cover a broad spectrum of activities important to the network goals including: database development, standardization of histopathology methods, development of novel measurement protocols, and phantom development. Projects were ranked and funds were awarded according to agreement with Network research priorities. A short summary of the projects’ specific aims, studies and results, significance, and plans is included in the sections that follow (E.1-E.8). 

 

Table E.1 lists awarded projects including principal investigator, performance institution, and title. Our three highest priority areas continue to include; Handheld probe platform standardization and reference platform standardization, Database Development and Computing Infrastructure Design, and Pathology Validation and Standardization.

 

 

Section	Principal Investigator	Title
E1	Wendy Wells, MD, MSc, Dartmouth Hitchcock Medical Center, Dartmouth Medical School	Pathological Correlation with MDDOT
E2	David Boas, PhD, Massachusetts General Hospital	Imaging probe for dynamic breast imaging to obtain images of oxygen consumption
E3	William Mantulin, PhD, University of California, Irvine (UCI)	Optical Phantoms for LBS Devices
E4	Lothar Lilge, PhD, University Health Network	A Transillumination Breast Spectroscopy System for Volumetric Assessment of Breast Optical Properties Associated with Breast Cancer Risk
E5	John Pearson, PhD SCR	Development of SciPort Collaboration System merged with Fast, Simple Organizer for NIR Data Banks
E6	Arjun Yodh, University of Pennsylvania	Combining Diffuse Optical Spectroscopy and Diffuse Optical Flow Measurements of Breast
E7	Albert Cerussi, PhD, University of California, Irvine, Fred Azar, PhD, Siemens Corporate Research	Three Dimensional Breast Anatomy Imaging System to Improve longitudinal Measurements of Breast Optical Properties
E8	Albert Cerussi, PhD, University of California, Irvine, Pai Chou, PhD, University of California, Irvine	Improvement of a portable frequency-domain instrument

Table E.1 A list of projects awarded developmental funds in Year 4.

 

 

 

 

Year 3

Nine developmental projects, totaling $250,000 (total costs), were awarded in Year 3. Of these projects two were new (E6 and E7), six of the projects began their second year of funding, and one was a result of a 2005 collaborative developmental project award.

 

Each application was reviewed based on innovation, relevance to Network goals, and investigators.. Funds were awarded to thirteen developmental projects covering a broad spectrum of activities including database development, standardization of histopathology methods, development of novel measurement protocols, and supporting student training. Projects were ranked and funds were awarded according to agreement with Network research priorities. A short summary for the first four projects, specific aims, studies and results, significance, and plans is included in the sections that follow. The other projects are summarized in the report that follows, as the work performed directly supplements the specific aims of those projects.

 

Table E.1 lists awarded projects including principal investigator, performance institution, and title. Our three highest priority areas continue to include:

• Handheld probe platform standardization and reference platform standardization
• Database Development and Computing Infrastructure Design.
• Pathology Validation and Standardization

 

Section	Principal Investigator	Title
E1	Wendy Wells, MD, Dartmouth Hitchcock Medical Center, Dartmouth Medical School	Pathological Correlation with MDDOT
E2	Birsen Yazici, PhD, Rensselaer Polytechnic Institute	Training and Collaboration Project between RPI, UPenn and Dartmouth
E3	Gregory Faris, PhD	Collaboration
E4	Lothar Lilge, PhD, University Health Network	A Transillumination Breast Spectroscopy System for Volumetric Assessment of Breast Optical Properties Associated with Breast Cancer Risk
Project 1	Albert Cerussi, PhD, University of California, Irvine (UCI), Fred Azar, PhD, Siemens Corporate Research (SCR)	Three Dimensional Breast Anatomy Imaging System to Improve longitudinal Measurements of Breast Optical Properties
Project 1	Arjun Yodh, University of Pennsylvania	Combining Diffuse Optical Spectroscopy and Diffuse Optical Flow Measurements of Breast
Project 1	Javad Rahimian, PhD and Ramesh C. Verma, MD, Olive View-University of California, Los Angeles Medical Center	Optical Characteristics of Breast Normal Tissue and Breast Masses Using a Clinical Laser Breast Scanner (LBS)
Software Core	John Pearson, PhD SCR, Britton Chance, PhD, MDRF	Phase 1 Development of SciPort Collaboration System merged with Fast, Simple Organizer for NIR Data Banks
Software Core	Fred Azar, Siemens Corporate Research (SCR)	Standardization & Training Workshop

Table E.1 A list of projects awarded developmental funds in Year 3

 

Year 2

Fourteen proposals were submitted in September 2004 for a share of $250,000 total costs. Each application was reviewed based on innovation, relevance to Network goals, and investigators.  Funds were awarded to thirteen developmental projects covering a broad spectrum of activities including database development, standardization of histopathology methods, development of novel measurement protocols, and supporting student training.

 

Projects were ranked and funds were awarded according to agreement with Network research priorities. A short summary for each project’s, specific aims, studies and results, significance, and plans is included in the sections that follow. Each project was reviewed by the Executive Committee with particular attention to the possibility of leveraging award funds. Table E.1 lists awarded projects including principal investigator, performance institution, title, amount awarded and leverage amount/source.  Leveraging NTROI funds accelerated the number of projects funded and stimulated collaborations.  As a result of receiving developmental project funds Dr. Wendy Wells collaborated with her department and institution to acquire a commercial image analysis system.  Those efforts came to fruition in April 2005 when a clinical laboratory contract was signed with Biogenix to include their iVision image analysis system, valued between $150,000 and $200,000.  Seed funding was awarded to projects that presented great potential for collaboration within the NCI Network.  Our three highest priority areas include:

• Handheld probe platform standardization and reference platform standardization
• Database Development and Computing Infrastructure Design.
• Pathology Validation and Standardization

Section	Principal Investigator	Title
E1	Albert Cerussi, PhD, University of California, Irvine (UCI), Fred Azar, PhD, Siemens Corporate Research (SCR)	Three Dimensional Breast Anatomy Imaging System to Improve longitudinal Measurements of Breast Optical Properties
E2	Britton Chance, PhD, Medical Diagnostic Research Foundation (MDRF)	Model System Performance Quantification of NTROI Imagers
E3	Britton Chance, PhD, MDRF	Articulated Pressure Quantified Breast Cancer NIR Sensor
E4	John Pearson, PhD SCR, Britton Chance, PhD, MDRF	Phase 1 Development of SciPort Collaboration System merged with Fast, Simple Organizer for NIR Data Banks
E5	Wendy Wells, MD, Dartmouth Hitchcock Medical Center, Dartmouth Medical School	Pathological Correlation with MDDOT
E6	Birsen Yazici, PhD, Rensselaer Polytechnic Institute	Training and Collaboration Project between RPI, UPenn and Dartmouth
E7	Arjun Yodh, PhD, UPENN Simon Arridge, PhD, University College, London	Inverse-Problem Software Development within TOAST
E8	Arjun Yodh, PhD, UPENN Bruce Tromberg, PhD, UCI	Combined Diffuse Optical Spectroscopy and Diffuse Optical Flow Measurements of Breast
E9	Pai Chou, PhD, UCI	NTROI Collaboration
E10	Gregory W. Faris, PhD, SRI International	NTROI Collaboration
E11	Gultekin Gulsen, PhD, UCI	NTROI Collaboration
E12	Vishal Saxena, PhD, University of Southern California	NTROI Collaboration
E13	Ramesh C. Verma, MD, Olive View-University of California, Los Angeles Medical Center	NTROI Collaboration

Table E.1 A list of projects awarded developmental funds awarded in Year 2.