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Laser Microbeam and Medical Program (LAMMP) Seminar

Angelique Y. Louie, Ph.D.
Professor and Vice Chair
Department of Biomedical Engineering
University of California, Davis
Angelique Y. Louie received the B.S. degree from the University of California, Davis, and the M.S. degree from the University of California, Los Angeles, both in electrical engineering. She received the Ph.D. degree in biological sciences from the University of California, Irvine. She held a Postdoctoral Fellowship at the California Institute of Technology, Pasadena. She is currently a Professor and Vice Chair in the Department of Biomedical Engineering, University of California, Davis. Her research focuses on the development of multimodal probes for molecular imaging. Recent work from her lab describes paramagnetic quantum dots, dual-mode agents to visualize atherosclerosis, activatable MRI agents, and nontoxic nanoparticles for MR/optical imaging.

Dr. Louie is a member of Tau Beta Pi, the Society of Women Engineers, and the Society for Molecular Imaging. She is an elected member of the Board of Directors for the Biomedical Engineering Society, elected Fellow of American Institute for Medical and Biological Engineering, and elected program director for the Cellular and Molecular Study section of the International Society for Magnetic Resonance in Medicine.
Multimodal Molecular Imaging
Friday, April 11, 2014
Beckman Laser Institute and Medical Clinic Library
Noon - 1 PM
(Lunch provided)
Abstract
The conundrum of modality selection in clinical diagnostic imaging is that modalities with the highest sensitivity have relatively poor resolution, while those with high resolution have relatively poor sensitivity. In recent years, the idea of using multiple modalities in conjunction has gained in popularity and researchers have come to realize that the complementary abilities of different imaging modalities could be harnessed to great effect by using them in tandem. The idea of combining imaging technologies moved to the mainstream with the advent of the first successful commercial fused instruments. The first fused PET/CT instrument, developed in 1998 by Townsend and colleagues in collaboration with Siemens Medical, was available commercially in 2001. Over the ensuing years PET/CT sales increased with such vigor that by the year 2006 there were virtually no sales of standalone PET instruments; all PET sales were as part of multimodality systems. Now PET/MRI instruments are poised to enter the clinic. With hybrid technology clearly on the rise, the excitement over these new instruments has triggered a tumult of activity in probe design and development in an effort to boost the clinical benefits of hybrid instrument technology. In this talk I present an overview of approaches to develop multimodal probes using current projects in my laboratory as examples with particular emphasis on PET/MR imaging of the vulnerable plaque.