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November 2020

Muyinatu Bell., Ph.D.

November 19, 2020 @ 12:00 pm - 1:30 pm
Zoom Event CA United States

Assistant Professor & PULSE Lab Director - Johns Hopkins University Department of Electrical and Computer Engineering Department of Biomedical Engineering Listening to the Sound of Light to Guide Surgeries Abstract Photoacoustic imaging offers “x-ray vision” to see beyond tool tips and underneath tissue during surgical procedures, yet no ionizing x-rays are required. Instead, optical fibers and acoustic receivers enable photoacoustic sensing of major structures – like blood vessels and nerves – that are otherwise hidden from view. The entire process…

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December 2020

Bioengineering for COVID-19

December 15, 2020 @ 12:30 am - 2:00 pm
Zoom Event CA United States

  Bioengineering for COVID-19: Rapid Acceleration of Diagnostics (RADx) at Unprecedented Speed and Scale Join Beall Applied Innovation and Beckman Laser Institute for a presentation from Bruce Tromberg, director of the National Institute of Biomedical Imaging and Bioengineering. Bruce will discuss how the NIH launched the Rapid Acceleration of Diagnostics initiative in response to the COVID-19 crisis. The virtual event is hosted by Richard Sudek, executive director at Beall Applied Innovation and chief innovation officer at UCI, and Tom Milner,…

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March 2021

Dr. Christoph Hitzenberger, Ph. D.

March 24, 2021 @ 10:00 am - 11:00 am
Zoom Event CA United States

From Ocular Biometry to Cellular Resolution – and Multifunctional OCT – Coherence Ranging and Imaging in the Human Eye over 35 Years Abstract In the mid 1980s, first applications of low coherence interferometry (LCI) to tissue metrology and analysis were reported. Starting from one-dimensional ocular biometry, the technology has evolved into a high-speed, 3-dimensional imaging technology, now known as optical coherence tomography (OCT), with a multitude of functional extensions that has revolutionized ocular diagnostics. This talk illustrates the evolution of…

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April 2021

Ji-Xi Cheng, Ph. D.

April 1, 2021 @ 12:00 pm - 1:00 pm
Zoom Event CA United States

Harnessing Photons for Label-free Chemical Imaging, High-Precision Neuromodulation, and Killing of Superbugs Abstract Photons are unique in that they can directly interact with molecules, the foundation of life. I will give an overview of our biophotonics research at three levels of interactions. At the weak interaction regime, I will present label-free chemical microscopy utilizing spectroscopic signals for discovery of molecular signatures related to cancer aggressiveness and antimicrobial resistance. At the moderate interaction regime, I will present non-genetic high-precision optoacoustic stimulation…

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Nozomi Nishimura, Ph. D.

April 22, 2021 @ 12:00 pm - 1:00 pm
Zoom Event CA United States

In vivo multiphoton microscopy of microvasculature and inflammation: Lessons from the brain and a look at the heart Abstract In vivo multiphoton microscopy enables the visualization of dynamics at the cellular scale and is an ideal tool for studying the interactions of cells in vivo. Such imaging has revealed the importance of maintaining vascular health, even in the smallest blood vessels and the capillary bed. In an example in the brain, we found in mouse models of Alzheimer’s disease (AD),…

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May 2021

Dan Cojoc, Ph. D.

May 6, 2021 @ 9:00 am - 10:00 am
Zoom Event CA United States

Cell Mechanics by Light Abstract Living cells are active matter characterized by mechanical properties as stiffness and deformability and morphological parameters as shape and volume. Genetic or pathogenic modifications of these properties can affect cell behavior. Since these transformations are potential indicators in various pathologies, cell mechanics characterization has progressively gained interest. However, due to their variability it is difficult to establish absolute values for these properties, especially when different measurement methods are applied. In the first part, I will…

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August 2021

Stacy Copp, Ph. D.

August 19, 2021 @ 12:00 pm - 1:00 pm
Zoom Event CA United States

Fluorophores with a Genome: DNA-Stabilized Silver Clusters as a New Class of Tunable Fluorophores for Microscopy and Biosensing Abstract Because near-infrared (NIR) electromagnetic radiation penetrates much farther into biological tissues than visible light, NIR microscopy allows for noninvasive imaging deep into tissues and even whole organisms. In the second near-infrared window (NIR-II: 1,000-1,700 nm), biological tissues are transparent up to several centimeters depth. However, fluorescence microscopy in this spectral window has been limited by the dearth of small, bright, and…

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October 2021

Erin Buckley, Ph. D.

October 14, 2021 @ 12:00 pm - 1:00 pm
Zoom Event CA United States

Illuminating Biomarkers of Stroke with Diffuse Optical Spectroscopies Abstract Our research group specializes in the development and application of diffuse optical spectroscopies to study the brain. These non-invasive, light-based tools enable real-time bedside monitoring of microvascular hemodynamics. In this seminar, I will focus on our recent work that uses these tools to identify biomarkers of stroke risk in two high-risk patient populations; subarachnoid hemorrhage and pediatric sickle cell disease. Moreover, I will talk about how we have advanced the techniques…

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December 2021

Wenbin Tan, Ph. D.

December 2, 2021 @ 12:00 pm - 1:00 pm
Zoom Event CA United States

Vasculopathy in COVID-19 and Pathogenesis of Cutaneous Vascular Malformations Abstract SARS-CoV-2-associated vasculopathy under hyperlipidemia and pathological progression of congenital vascular abnormalities in Port Wine Stains. In the first part, we will present our clinical data for the first discovery of dyslipidemia in COVID-19 patients which have been substantially recognized. Mechanistically, we have shown evidence of niche why obese subjects are more vulnerable to SARS-CoV-2 attack. Using a spike protein–pseudotyped (Spp) lentivirus with the proper tropism of the SARS-CoV-2 spike protein…

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Song Hu, Ph. D.

December 16, 2021 @ 12:00 pm - 1:00 pm
Zoom Event CA United States

Light + Sound: Peering into Brain Function and Metabolism Abstract Exploiting the optical absorption contrast of blood hemoglobin, photoacoustic microscopy (PAM) is an emerging technology for label-free imaging of the microvasculature, which plays an essential role in supplying oxygen to the biological tissue and maintaining the metabolic activity in vivo. The multi-parametric PAM developed in Dr. Hu’s lab enables, for the first time, comprehensive and quantitative characterization of the microvascular structure, function, and associated tissue oxygen metabolism at the microscopic…

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