The 2nd Annual Allan R. Oseroff Photomedicine Lecture

Thursday 25th of February 2010
12:00 PM
Beckman Laser Institute Library

Steven Hahn

The Future of Clinical PDT-Bringing Science to Patient Care

Steven M. Hahn, MD
University of Pennsylvania Health System Chair, Department of Radiation Oncology, Director, Photodynamic Therapy Program

Many applications of PDT in the clinic today are limited by a narrow therapeutic index. However, there are a remarkable number of preclinical studies that have investigated basic mechanisms of PDT action. Biologically-based studies have shown that targeting signaling pathways selectively enhance the effect of PDT in human tumor models. Optical studies have demonstrated that measurement of individual patient optical properties may increase the efficacy of light regimens. Translation of these results into clinical trials has the potential to improve the therapeutic index of PDT and by extension possibly improve patient outcome.

About the Speaker:
Stephen M. Hahn, MD is the Chair and Henry K. Pancoast Professor of Radiation Oncology at the University of Pennsylvania School of Medicine. Dr. Hahn is an active clinician, with particular expertise in treating lung and genitourinary cancers and in the use of photodynamic therapy. Board certified in Internal Medicine, Radiation Oncology, and Hematology/Oncology, Hahn received his medical degree from Temple University School of Medicine and his undergraduate degrees from Rice University. In 1987, he completed his residency and served as Chief Resident of Internal Medicine at the University of California, San Francisco. Hahn also completed a Medical Oncology Fellowship at the NCI in 1991, and a Radiation Oncology Residency at the NCI in 1994. Prior to joining Penn in 1996, Hahn was a Medical and Radiation Oncologist in Santa Rosa, CA. From 1993-95, he served as Chief of the National Cancer Institute.s Prostate Cancer Clinic, Clinical Pharmacology Branch, in Bethesda, MD, and a senior investigator at the NCI. Hahn also served as a Commander in the NCI.s U.S. Public Health Service from 1989-95. After joining Penn in 1996, Hahn served as an Assistant Professor of Radiation Oncology and Hematology/Oncology until 2001, when he was appointed Associate Professor. For the past several years, Hahn has served as Director of Penn.s Photodynamic Therapy program, which treats cancer patients through a minimally invasive process that uses a photosensitizer and concurrent laser light to selectively destroy tumors. He also directs the Farnesyltransferase Inhibitor Program for Treatment of cancer of the lung, head and neck and pancreas. In addition, Hahn is the Co-Program Leader of the Radiation Biology and Imaging Research Program in the Abramson Cancer Center of the University of Pennsylvania. Hahn currently serves as a Senior Editor of Clinical Cancer Research and is a long standing member of the American Society of Therapeutic Radiation Oncology, the American Society of Clinical Oncology, the Radiation Research Society, the American Society of Photobiology, the American Association for Cancer Research, and the University of Pennsylvania.s John Morgan Society.

About Dr. Oseroff
The 1st Annual Allan R. Oseroff Photomedicine Lecture