MacLean Professor of Engineering, Dartmouth
Editor-in-Chief, Journal of Biomedical Optics, SPIE Press
While the field of Medical Imaging is dominated by radiological devices, the field of Imaging Medicine today is dominated by optical devices. Optical imaging is commonly used at the point-of-care, where patient and physician are in the same room together. These procedure-based tools are used to capture unique contrast features that help guide medical decisions. In the Optics in Medicine cluster at Dartmouth scientific discovery and technology development are advanced side-by-side in areas such as image-guided spectroscopy of cancer, surgical guidance tools with molecular specificity, smart photodynamic therapy, and novel radiologic guidance and dosimetry tools for remote non-contact monitoring of Cherenkov and scintillation light. Examples from each will be used to highlight innovations in translational research that have gone from scientific concept through to technology development and into clinical trials. Translating optical Imaging systems beyond the pilot trial phase involves the type of R&D which only companies can accomplish, and so examples of strategic partnerships with companies in translational research will be shown. Venture creation through a startup company, DoseOptics LLC, will be highlighted in which this pathway has enabled testing and deployment of a fundamentally new technology to image radiation dose delivery in real time for the first time in history, and extended to multiple cancer centers. The invention and translation of new optical tools to Image Medicine is an enormous economic force today, and the growth in science and technology opportunities and NIH funding within this field is discussed.
Brian W. Pogue, Ph.D. is the MacLean Professor of Engineering at Dartmouth in Hanover, New Hampshire USA, and is Adjunct Professor in Surgery at the Geisel School of Medicine and Adjunct Professor of Life Science & Technology at Xi’an Jiaotong University, China. His Doctoral work in Physics from McMaster University, Canada, was followed by a Research Fellow position at the Wellman Center for Photomedicine at Harvard Medical School. At Dartmouth since 1996, he works in the area of Optics in Medicine, with a focus on novel imaging systems for characterizing cancer and tracking therapy. Following being Dean of Graduate Studies at Dartmouth from 2008-2012, he is now Director of MS and PhD Programs in Engineering Science & Medical Physics and coordinates the Center for Imaging Medicine. He has published over 350 peer-reviewed papers and 400 conference papers in cancer therapy, surgery, medicine, medical oncology, and radiotherapy. His research is funded by the NIH through two Program Project grants as well as several individual R01 grants. He is the Editor-in-Chief of the Journal of Biomedical Optics published by SPIE and is a Fellow of the International Society for Optics and Photonics (SPIE), the Optical Society of America (OSA) and the American Institute of Medical and Biological Engineers (AIMBE). He recently founded the startup company DoseOptics LLC, making the world’s first camera to image radiotherapy dose delivery.
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